标题：CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell Acute Lymphoblastic Leukemia

作者：Passaro D1, Irigoyen M2, Catherinet C2, Gachet S2, Da Costa De Jesus C2, Lasgi C2, Tran Quang C2, Ghysdael J3.

网址:http://www.ncbi.nlm.nih.gov/pubmed/26058076

求助者：muyanch

• 求助时间：2015/6/13 9:52:14
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• 文献摘要：

Impaired cell migration has been demonstrated in T cell acute lymphoblastic leukemia (T-ALL) cells upon calcineurin inactivation, among other phenotypic traits including increased apoptosis, inhibition of cell proliferation, and ultimately inhibition of leukemia-initiating cell (LIC) activity. Herein we demonstrate that the chemokine receptor CXCR4 is essential to the LIC activity of T-ALL leukemic cells both in NOTCH-induced mouse T-ALL and human T-ALL xenograft models. We further demonstrate that calcineurin regulates CXCR4 cell-surface expression in a cortactin-dependent manner, a mechanism essential to the migratory properties of T-ALL cells. Because 20%-25% of pediatric and over 50% of adult patients with T-ALL do not achieve complete remission and relapse, our results call for clinical trials incorporating CXCR4 antagonists in T-ALL treatment.

Copyright © 2015 Elsevier Inc. All rights reserved.

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