标题：Neurotoxic effects of intrathecal magnesium sulphate

作者：Ozdogan L1, Sastim H1, Ornek D2, Postaci A1, Ayerden T1, Dikmen B1.

网址:PMID: 24565097

求助者：306

• 求助时间：2015/6/14 15:23:29
• 求助状态：AB图书馆客服已找到全文，详情咨询在线客服qq 1257749646
• 文献摘要：

BACKGROUND AND OBJECTIVES:

To assess the potential neurotoxic effects at the ultrastructural level of magnesium sulfate administered intrathecally as a single or multi-dose.

METHODS:

Our study was conducted with 24 Sprague-Dawley rats that weighed 250-300 g. After a 4-hour fast, the rats were given 10 mg.kg(-1) xylazine chloride intraperitoneal and then randomly allocated into three groups. Group I (n = 8) received 0.9% normal saline, Group II (n = 8) was given one intrathecal injection of 0.02 mL of 15% magnesium sulphate, and Group III (n = 8) was given 0.02 mL of 15% magnesium sulphate once a day for seven days. The injections were given within 0.40x50 mm from the lumbar area. After seven days, the animals were sacrificed under anesthesia with an aortic injection of 10% formaldehyde and their tissues were fixed. The medulla spinalis was then examined and histopathologically evaluated under an electron microscope. The Kruskal-Wallis test was used for statistical evaluation. A value of p < .05 was considered to be statistically significant.

RESULTS:

Significant neurodegeneration was detected in rats given single or repeated magnesium sulphate injections compared to the control group. The histopathological evaluation score of this group was also high.

CONCLUSIONS:

Based on electron microscopic examination, we found that intrathecal magnesium sulphate administration induced neurodegeneration.

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