标题：TGF-beta stimulation of endometrial and breast-cancer cell growth

作者：Croxtall JD1, Jamil A, Ayub M, Colletta AA, White JO.

网址:PMID: 1312067

求助者：秋风之

• 求助时间：2015/6/18 11:10:07
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• 文献摘要：

Growth of the human endometrial carcinoma Ishikawa cell line was stimulated by transforming growth factor-beta1 when cultured in serum-containing and chemically defined culture medium. This response was not unique to endometrial carcinoma cells, as the breast-cancer cell line, T47-D, was similarly stimulated by TGF-beta 1. TGF-beta 1 stimulated growth of MCF-7 breast-cancer cells in chemically defined medium but inhibited growth of this cell line in serum-containing medium. The data provide a demonstration of a positive growth response to TGF-beta 1 in oestrogen-receptor-positive cells and do not support the hypothesis that this growth factor is simply a negative growth regulator in epithelial-cancer cell lines.

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