标题：Coamplification of the L-myc and N-myc oncogenes in a neuroblastoma cell line

作者：Jinbo T1, Iwamura Y, Kaneko M, Sawaguchi S.

网址:PMID: 2501244

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• 求助时间：2015/7/29 10:22:25
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• 文献摘要：

The L-myc, N-myc and c-myc genes are members of the myc oncogene family. In particular, L-myc is novel, and amplification of L-myc is still unknown except in small cell lung carcinoma. We examined L-myc amplification in 30 human neuroblastomas using Southern blot hybridization, and found that the L-myc gene was amplified approximately 5-fold in GOTO, a human neuroblastoma cell line. The N-myc gene was also amplified approximately 60-fold and furthermore, over-expression of L-myc and N-myc genes was observed in this cell line. In this report, we describe the coamplification of the myc gene family in the GOTO neuroblastoma cell line.

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