标题：Absolute Binding Affinity Calculation for MDM2 Bound to a Disordered Fragment of P53

作者：Yingqian Zhan F. Marty Ytreberg F. Marty Ytreberg

网址:258759050_Absolute_Binding_Affinity_Calculation_for_MDM2_Bound_to_a_Disordered_Fragment_of_P53

求助者：雨后晴天

• 求助时间：2015/8/26 16:24:09
• 文献摘要：

Accurate calculation of of protein-protein binding affinities remains a key challenge in computational biophysics and biochemistry. This challenge is even more acute when one binding partner is intrinsically disordered in its unbound state. In this study, a potential mean force (PMF) method was used to calculate the absolute binding affinity for MDM2 and the intrinsically disordered protein (IDP) fragment of p53.